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Human Type 3 IP3 Receptor - Labile Resting State 1 (+IP3/ATP)

Electron Microscopy
3.5Å resolution
PDB entry 8tkh coloured by chain, front view.
PDB entry 8tkh coloured by chain, side view.
PDB entry 8tkh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
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Multimeric state: homo tetramer
Accessible surface area: 418288.15 Å2
Buried surface area: 30972.23 Å2
Dissociation area: 13,129.71 Å2
Dissociation energy (ΔGdiss): 145.31 kcal/mol
Dissociation entropy (TΔSdiss): 59.94 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-172038

Macromolecules

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
Chains: A, B, C, D
Length: 2671 amino acids
Theoretical weight: 304.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14573 (Residues: 1-2671; Coverage: 100%)
Gene name: ITPR3
Pfam:
Inositol 1,4,5-trisphosphate receptor type 3 in PDB entry 8tkh, assembly 1, front view.
Inositol 1,4,5-trisphosphate receptor type 3 in PDB entry 8tkh, assembly 1, side view.
Inositol 1,4,5-trisphosphate receptor type 3 in PDB entry 8tkh, assembly 1, top view.
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