› 8tlw

X-ray diffraction
2.11Å resolution

Crystal structure of MBP and AF9 AHD fusion protein 3AQA in complex with peptidomimetic inhibitor 28

Released:
DOI: 10.2210/pdb8tlw/pdb
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PDB entry 8tlw coloured by chain, front view.
PDB entry 8tlw coloured by chain, side view.
PDB entry 8tlw coloured by chain, top view.
Source organisms:
Primary publication:
Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors.
Yang Y, Ahmad E, Premkumar V, Liu A, Ashikur Rahman SM, Nikolovska-Coleska Z
OpenAccess logo Protein Sci 33 e5019 (2024)
PMID: 38747396

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244789 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Maltose/maltodextrin-binding periplasmic protein; Protein AF-9 Chain: A
Molecule details ›
Chain: A
Length: 442 amino acids
Theoretical weight: 48.89 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: P42568 (Residues: 500-568; Coverage: 12%)
Gene names: AF9, JW3994, MLLT3, YEATS3, b4034, malE
Sequence domains:
peptidomimetic inhibitor 28 Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 819 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
2 modified residues:
Ligand DPP 1 x DPP
Ligand XYC 1 x XYC

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P41212
Unit cell:
a: 75.701Å b: 75.701Å c: 170.789Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.176 0.213
Expression systems:
  • Escherichia coli
  • Not provided

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