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nhTMEM16 lipid scramblase in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (open state)

Electron Microscopy
2.85Å resolution
PDB entry 8tol coloured by chain, front view.
PDB entry 8tol coloured by chain, side view.
PDB entry 8tol coloured by chain, top view.
Source organism: Fusarium vanettenii 77-13-4
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Plasma membrane channel protein
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Multimeric state: homo dimer
Accessible surface area: 60831.24 Å2
Buried surface area: 17962.62 Å2
Dissociation area: 5,479.11 Å2
Dissociation energy (ΔGdiss): 61.28 kcal/mol
Dissociation entropy (TΔSdiss): 16.94 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-111787

Macromolecules

Plasma membrane channel protein
Chains: A, B
Length: 737 amino acids
Theoretical weight: 83.29 KDa
Source organism: Fusarium vanettenii 77-13-4
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: C7Z7K1 (Residues: 2-735; Coverage: 100%)
Gene name: NECHADRAFT_66456
Pfam:
Plasma membrane channel protein in PDB entry 8tol, assembly 1, front view.
Plasma membrane channel protein in PDB entry 8tol, assembly 1, side view.
Plasma membrane channel protein in PDB entry 8tol, assembly 1, top view.
PDBe-KB: UniProt Coverage View: C7Z7K1  
1737100200300400500600700
 
200400600GPSNLKDFSQPGSGQESNFGVDFVIHYKVPAAERDEAEAGFVQLIRALTTVGLATEVRHGENESLLVFVKVASPDLFAKQVYRARLGDWLHGVRVSAPHNDIAQALQDEPVVEAERLRLIYLMITKPHNEGGAGVTPTNAKWKHVESIFPLHSHSFNKEWIKKWSSKYTLEQTDIDNIRDKFGESVAFYFAFLRSYFRFLVIPSAFGFGAWLLLGQFSYLYALLCGLWSVVFFEYWKKQEVDLAVQWGVRGVSSIQQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGPGKQYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDAHDAALIQKQFVLNFMTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQKAKQLKSGSKVQEDHEEEAEFLQRVREECTLEEYDVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSRRPIPWRTDSIGPWLTALSFLSWLGSITSSAIVYLCSNSKNGTQGEASPLKAWGLLLSILFAEHFYLVVQLAVRFVLSKLDSPGLQKERKERFQTKKRLLQENLGQDAAEEAAAPGIEHSEKITREALEEEARQASIRGHGTPEEMFWQRQRGMQETIEIGRRMIEQQLAAGKNGKKSAPAVPSEKASA
UniProt
C7Z7K1
Chains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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