› 8tor

X-ray diffraction
2.2Å resolution

Function and Biology Details

Reaction catalysed: 
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-239717 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Processed angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 625 amino acids
Theoretical weight: 72.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 18-614; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme
Peptide 2 Chain: E
Molecule details ›
Chain: E
Length: 15 amino acids
Theoretical weight: 1.73 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand GOL 3 x GOL
Ligand NAG 1 x NAG
Ligand CL 1 x CL
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: R3
Unit cell:
a: 180.199Å b: 180.199Å c: 70.068Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.18 0.206
Expression systems:
  • Homo sapiens
  • Not provided

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