› 8tpt

Electron Microscopy
3.01Å resolution

nhTMEM16 A444P mutant in lipid nanodiscs with MSP1E3 scaffold protein in the presence of Ca2+ (long TM6/short TM6)

Released:
DOI: 10.2210/pdb8tpt/pdb
PDB entry 8tpt coloured by chain, front view.
PDB entry 8tpt coloured by chain, side view.
PDB entry 8tpt coloured by chain, top view.
Source organism: Fusarium vanettenii 77-13-4
Primary publication:
Structural basis of closed groove scrambling by a TMEM16 protein.
Feng Z, Alvarenga OE, Accardi A
Nat Struct Mol Biol (2024)
PMID: 38684930
Related structures: EMD-41484

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma membrane channel protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 737 amino acids
Theoretical weight: 83.32 KDa
Source organism: Fusarium vanettenii 77-13-4
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: C7Z7K1 (Residues: 2-735; Coverage: 100%)
Gene name: NECHADRAFT_66456
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand PGW 4 x PGW
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.01Å
Relevant EMDB volumes: EMD-41484
Expression system: Saccharomyces cerevisiae

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