8tqi

Electron Microscopy
3.24Å resolution

Hemagglutinin-neuraminidase from Human parainfluenza virus type 3: complex with rPIV3-23 and rPIV3-28 Fabs

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-243425 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin-neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 454 amino acids
Theoretical weight: 50.77 KDa
Source organism: Human respirovirus 3
Expression system: Homo sapiens
Heavy chain Fab rPIV3-28 Chains: C, H
Molecule details ›
Chains: C, H
Length: 223 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Light chain Fab rPIV3-28 Chains: D, L
Molecule details ›
Chains: D, L
Length: 214 amino acids
Theoretical weight: 23.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Heavy chain Fab rPIV3-23 Chains: E, I
Molecule details ›
Chains: E, I
Length: 235 amino acids
Theoretical weight: 24.95 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Light chain Fab rPIV3-23 Chains: F, J
Molecule details ›
Chains: F, J
Length: 213 amino acids
Theoretical weight: 23.31 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.24Å
Relevant EMDB volumes: EMD-41505
Expression systems:
  • Homo sapiens
  • Cricetulus griseus