› 8tr9

Electron Microscopy
3.2Å resolution

Cryo-EM structure of transglutaminase 2 bound to GDP

Released:
DOI: 10.2210/pdb8tr9/pdb
PDB entry 8tr9 coloured by chain, front view.
PDB entry 8tr9 coloured by chain, side view.
PDB entry 8tr9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Aplin C, Cerione RA
Related structures: EMD-41574

Function and Biology Details

Reactions catalysed: 
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)-(gamma-glutamyl)-L-lysine cross-link + NH(3)
Protein L-glutamine + H(2)O = protein L-glutamate + NH(3)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149488 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-glutamine gamma-glutamyltransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 687 amino acids
Theoretical weight: 77.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21980 (Residues: 1-687; Coverage: 100%)
Gene name: TGM2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-41574
Expression system: Escherichia coli BL21(DE3)

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