› 8trd

Electron Microscopy
3.4Å resolution

mGluR3 class 1 in the presence of the antagonist LY 341495

Released:
DOI: 10.2210/pdb8trd/pdb
PDB entry 8trd coloured by chain, front view.
PDB entry 8trd coloured by chain, side view.
PDB entry 8trd coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Arefin A, Huynh K, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
Nat Commun 15 6498 (2024)
PMID: 39090128
Related structures: EMD-41578

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 921 amino acids
Theoretical weight: 103.16 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P31422 (Residues: 1-879; Coverage: 100%)
Gene names: Gprc1c, Grm3, Mglur3
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand Z99 2 x Z99
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-41578
Expression system: Homo sapiens

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