› 8trj

Electron Microscopy
2.78Å resolution

Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP

Released:
DOI: 10.2210/pdb8trj/pdb
PDB entry 8trj coloured by chain, front view.
PDB entry 8trj coloured by chain, side view.
PDB entry 8trj coloured by chain, top view.
Source organism: Rattus
Primary publication:
High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket.
Oken AC, Lisi NE, Krishnamurthy I, McCarthy AE, Godsey MH, Glasfeld A, Mansoor SE
Nat Commun 15 6662 (2024)
PMID: 39107314
Related structures: EMD-41581

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor 7 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 595 amino acids
Theoretical weight: 68.47 KDa
Source organism: Rattus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64663 (Residues: 1-595; Coverage: 100%)
Gene name: P2rx7
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand KD9 3 x KD9
Ligand GDP 3 x GDP
Ligand ZN 6 x ZN
Ligand NAG 9 x NAG
Ligand PLM 15 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.78Å
Relevant EMDB volumes: EMD-41581
Expression system: Homo sapiens

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