› 8trv

X-ray diffraction
3.25Å resolution

Structure of the EphA2 LBDCRD bound to FabS1C_C1

Released:
DOI: 10.2210/pdb8trv/pdb
PDB entry 8trv coloured by chain, front view.
PDB entry 8trv coloured by chain, side view.
PDB entry 8trv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Singer AU, Bruce HA, Blazer L, Adams JJ, Sicheri F, Sidhu SS

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273501 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ephrin type-A receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 33.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P29317 (Residues: 23-326; Coverage: 32%)
Gene names: ECK, EPHA2
Sequence domains: Ephrin receptor ligand binding domain
S1C variant of Fab_C1 heavy chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 223 amino acids
Theoretical weight: 23.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
S1C variant of Fab_C1 light chain Chains: E, G
Molecule details ›
Chains: E, G
Length: 215 amino acids
Theoretical weight: 23.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

4 bound ligands:
Ligand IOD 5 x IOD
Ligand CL 10 x CL
Ligand NA 4 x NA
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Unit cell:
a: 73.933Å b: 110.558Å c: 263.443Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.272
Expression system: Homo sapiens

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