8ttw

Electron Microscopy
2.96Å resolution

Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-235381 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (10 distinct):
Transmembrane protein gp41 Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-510; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Transmembrane protein gp41 Chains: B, F, J
Molecule details ›
Chains: B, F, J
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S5 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Antibody 8anc195 heavy chain Chains: C, G, K
Molecule details ›
Chains: C, G, K
Length: 238 amino acids
Theoretical weight: 25.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody 8anc195 light chain Chains: D, H, L
Molecule details ›
Chains: D, H, L
Length: 215 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody 10-1074 heavy chain Chains: M, O, Q
Molecule details ›
Chains: M, O, Q
Length: 238 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody 10-1074 light chain Chains: N, P, R
Molecule details ›
Chains: N, P, R
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.96Å
Relevant EMDB volumes: EMD-41613
Expression system: Homo sapiens