› 8tyf

X-ray diffraction
2.59Å resolution

Plasmodium vivax PMV-WM06 inhibitor complex

Released:
DOI: 10.2210/pdb8tyf/pdb
PDB entry 8tyf coloured by chain, front view.
PDB entry 8tyf coloured by chain, side view.
PDB entry 8tyf coloured by chain, top view.
Source organism: Plasmodium vivax Sal-1
Entry authors: Hodder AN, Scally SW, Czabotar PE, Cowman AF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-500624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasmepsin V Chain: A
Molecule details ›
Chain: A
Length: 461 amino acids
Theoretical weight: 52.68 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A5K302 (Residues: 35-476; Coverage: 88%)
Gene names: PMV, PVX_116695
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand T0F 1 x T0F
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I222
Unit cell:
a: 60.72Å b: 81.85Å c: 192.876Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.241
Expression system: Spodoptera frugiperda

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