› 8tzc

Electron Microscopy
2.7Å resolution

Structure of C-terminal LRRK2 bound to MLi-2 (G2019S mutant)

Released:
DOI: 10.2210/pdb8tzc/pdb
PDB entry 8tzc coloured by chain, front view.
PDB entry 8tzc coloured by chain, side view.
PDB entry 8tzc coloured by chain, top view.
Source organisms:
Primary publication:
Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.
Sanz Murillo M, Villagran Suarez A, Dederer V, Chatterjee D, Alegrio Louro J, Knapp S, Mathea S, Leschziner AE
OpenAccess logo Sci Adv 9 eadk6191 (2023)
PMID: 38039358
Related structures: EMD-41754

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236322 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leucine-rich repeat serine/threonine-protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 1195 amino acids
Theoretical weight: 136.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5S007 (Residues: 1333-2527; Coverage: 47%)
Gene names: LRRK2, PARK8
Sequence domains:
E11 DARPin Chain: B
Molecule details ›
Chain: B
Length: 182 amino acids
Theoretical weight: 19.77 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand A1N 1 x A1N
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-41754
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

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Citations

1 review citation

Lysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies.
Dai et al. (2024)
5 other articles