8tzr

Electron Microscopy
3.5Å resolution

Structure of human Wnt3a bound to WLS and CALR

Released:
Source organism: Homo sapiens
Related structures: EMD-41767

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-232454 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Protein Wnt-3a Chain: A
Molecule details ›
Chain: A
Length: 352 amino acids
Theoretical weight: 39.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P56704 (Residues: 1-352; Coverage: 100%)
Gene name: WNT3A
Sequence domains: wnt family
Protein wntless homolog Chain: B
Molecule details ›
Chain: B
Length: 541 amino acids
Theoretical weight: 62.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5T9L3 (Residues: 1-541; Coverage: 100%)
Gene names: C1orf139, GPR177, UNQ85/PRO18667, WLS
Sequence domains:
Calreticulin Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GLC
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-41767
Expression system: Homo sapiens