› 8u3l

Electron Microscopy
3.7Å resolution

TRPV1 in nanodisc bound with empty vanilloid binding pocket at 25C

Released:
DOI: 10.2210/pdb8u3l/pdb
PDB entry 8u3l coloured by chain, front view.
PDB entry 8u3l coloured by chain, side view.
PDB entry 8u3l coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Arnold WR, Mancino A, Moss FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024)
PMID: 38698206
Related structures: EMD-41866

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 815 amino acids
Theoretical weight: 92.65 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35433 (Residues: 1-838; Coverage: 97%)
Gene names: Trpv1, Vr1, Vr1l
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 3PH 4 x 3PH
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-41866
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Structural basis of TRPV1 inhibition by SAF312 and cholesterol.
Fan et al. (2024)