› 8u3z

Electron Microscopy
3.6Å resolution

Model of TTLL6 bound to microtubule from composite map

Released:
DOI: 10.2210/pdb8u3z/pdb
PDB entry 8u3z coloured by chain, front view.
PDB entry 8u3z coloured by chain, side view.
PDB entry 8u3z coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for α-tubulin-specific and modification state-dependent glutamylation.
Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
Nat Chem Biol (2024)
PMID: 38658656
Related structures: EMD-41090

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-269834 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tubulin alpha-1B chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68363 (Residues: 1-451; Coverage: 100%)
Gene name: TUBA1B
Sequence domains:
Tubulin beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 444 amino acids
Theoretical weight: 49.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P07437 (Residues: 1-444; Coverage: 100%)
Gene names: OK/SW-cl.56, TUBB, TUBB5
Sequence domains:
Tubulin polyglutamylase TTLL6 Chain: N

Ligands and Environments

4 bound ligands:
Ligand GTP 2 x GTP
Ligand MG 5 x MG
Ligand G2P 2 x G2P
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.6Å
Relevant EMDB volumes: EMD-41090
Expression system: Escherichia coli

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