› 8u4i

Electron Microscopy
3.38Å resolution

Structure of the HER4/NRG1b Homodimer Extracellular Domain

Released:
DOI: 10.2210/pdb8u4i/pdb
PDB entry 8u4i coloured by chain, front view.
PDB entry 8u4i coloured by chain, side view.
PDB entry 8u4i coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Trenker R, Diwanji D, Bingham T, Verba KA, Jura N
Related structures: EMD-41883

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241645 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Receptor tyrosine-protein kinase erbB-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 610 amino acids
Theoretical weight: 68.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15303 (Residues: 26-635; Coverage: 48%)
Gene names: ERBB4, HER4
Sequence domains:
Neuregulin-1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 52 amino acids
Theoretical weight: 5.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02297 (Residues: 177-225; Coverage: 8%)
Gene names: GGF, HGL, HRGA, NDF, NRG1, SMDF
Sequence domains: EGF-like domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.38Å
Relevant EMDB volumes: EMD-41883
Expression systems:
  • Homo sapiens
  • Escherichia coli

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