› 8u5n

Electron Microscopy
3Å resolution

The mTORC1 cholesterol sensor LYCHOS (GPR155) - monomer with auxin

Released:
DOI: 10.2210/pdb8u5n/pdb
PDB entry 8u5n coloured by chain, front view.
PDB entry 8u5n coloured by chain, side view.
PDB entry 8u5n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR.
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024)
PMID: 39358511
Related structures: EMD-41929

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275013 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysosomal cholesterol signaling protein Chain: A
Molecule details ›
Chain: A
Length: 890 amino acids
Theoretical weight: 99.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z3F1 (Residues: 1-870; Coverage: 100%)
Gene names: GPR155, PGR22
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand IAC 1 x IAC
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-41929
Expression system: Homo sapiens

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