› 8u86

Electron Microscopy
3.3Å resolution

Structural Basis of Human NOX5 Activation

Released:
DOI: 10.2210/pdb8u86/pdb
PDB entry 8u86 coloured by chain, front view.
PDB entry 8u86 coloured by chain, side view.
PDB entry 8u86 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of human NOX5 activation.
Cui C, Jiang M, Jain N, Das S, Lo YH, Kermani AA, Pipatpolkai T, Sun J
Nat Commun 15 3994 (2024)
PMID: 38734761
Related structures: EMD-42015

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADPH oxidase 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 719 amino acids
Theoretical weight: 82.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96PH1 (Residues: 19-765; Coverage: 94%)
  • Best match: Q96PH1-3 (Residues: 19-737)
Gene name: NOX5
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand HEB 4 x HEB
Ligand NDP 2 x NDP
Ligand FAD 2 x FAD
Ligand D12 2 x D12
Ligand D10 2 x D10
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-42015
Expression system: Homo sapiens

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