› 8u8a

Electron Microscopy
3.4Å resolution

Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib

Released:
DOI: 10.2210/pdb8u8a/pdb
PDB entry 8u8a coloured by chain, front view.
PDB entry 8u8a coloured by chain, side view.
PDB entry 8u8a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM.
Zhu H, Hixson P, Ma W, Sun J
OpenAccess logo Cell Discov 10 10 (2024)
PMID: 38263358
Related structures: EMD-42019

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177795 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: B, C
Molecule details ›
Chains: B, C
Length: 2527 amino acids
Theoretical weight: 286.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5S007 (Residues: 1-2527; Coverage: 100%)
Gene names: LRRK2, PARK8
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 0LI 2 x 0LI
Ligand GDP 2 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-42019
Expression system: Homo sapiens

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