› 8uby

Electron Microscopy
2.67Å resolution

Choline-bound FLVCR1

Released:
DOI: 10.2210/pdb8uby/pdb
PDB entry 8uby coloured by chain, front view.
PDB entry 8uby coloured by chain, side view.
PDB entry 8uby coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1.
Son Y, Kenny TC, Khan A, Birsoy K, Hite RK
Nature (2024)
PMID: 38693265
Related structures: EMD-42109

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275528 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline/ethanolamine transporter FLVCR1 Chain: A
Molecule details ›
Chain: A
Length: 555 amino acids
Theoretical weight: 59.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5Y0 (Residues: 1-555; Coverage: 100%)
Gene names: FLVCR, FLVCR1
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

2 bound ligands:
Ligand Y01 3 x Y01
Ligand CHT 1 x CHT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.67Å
Relevant EMDB volumes: EMD-42109
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Unearthing FLVCR1a: tracing the path to a vital cellular transporter.
Fiorito et al. (2024)