8uck

Electron Microscopy
3.26Å resolution

Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human VMAT2

Released:
Entry authors: Ye J, Liu B, Li W
Related structures: EMD-42129

Function and Biology Details

Reaction catalysed:
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-281047 (preferred)
Entry contents:
10 distinct polypeptide molecules
Macromolecules (10 distinct):
Synaptic vesicular amine transporter Chain: A
Molecule details ›
Chain: A
Length: 514 amino acids
Theoretical weight: 55.75 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q05940 (Residues: 1-514; Coverage: 100%)
Gene names: SLC18A2, SVMT, VMAT2
Sequence domains: Major Facilitator Superfamily
Cytochrome c oxidase subunit 1 Chain: a
Molecule details ›
Chain: a
Length: 535 amino acids
Theoretical weight: 58.86 KDa
Source organism: Komagataella pastoris
UniProt:
  • Canonical: F2R0K8 (Residues: 1-535; Coverage: 100%)
Gene names: COX1, PP7435_Mit-0220
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase subunit 2 Chain: b
Cytochrome c oxidase subunit 3 Chain: c
Cytochrome c oxidase subunit Chain: d
Cytochrome c oxidase subunit 5B Chain: e
Cytochrome c oxidase subunit 6, mitochondrial Chain: f
Cytochrome c oxidase subunit 7 Chain: g
Cytochrome c oxidase subunit 8, mitochondrial Chain: h
Cytochrome c oxidase subunit 9, mitochondrial Chain: i

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-42129
Expression system: Komagataella pastoris