› 8ucq

Electron Microscopy
3.7Å resolution

CryoEM structure of Sec7 autoinhibited conformation

Released:
DOI: 10.2210/pdb8ucq/pdb
PDB entry 8ucq coloured by chain, front view.
PDB entry 8ucq coloured by chain, side view.
PDB entry 8ucq coloured by chain, top view.
Source organism: Thermothielavioides terrestris
Primary publication:
Sec7 regulatory domains scaffold autoinhibited and active conformations.
Brownfield BA, Richardson BC, Halaby SL, Fromme JC
Proc Natl Acad Sci U S A 121 e2318615121 (2024)
PMID: 38416685
Related structures: EMD-42135

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SEC7 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 1937 amino acids
Theoretical weight: 215.56 KDa
Source organism: Thermothielavioides terrestris
Expression system: Komagataella pastoris
UniProt:
  • Canonical: A0A3S5CXE1 (Residues: 2-1786; Coverage: 99%)
Gene name: TT172_LOCUS6419
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-42135
Expression system: Komagataella pastoris

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