› 8udz

X-ray diffraction
2.21Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-247141 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Transforming growth factor beta-1 proprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 361 amino acids
Theoretical weight: 41.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01137 (Residues: 30-390; Coverage: 100%)
Gene names: TGFB, TGFB1
Sequence domains:
LTBP-49247 Fab Heavy Chain Chains: C, E
Molecule details ›
Chains: C, E
Length: 233 amino acids
Theoretical weight: 25.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
LTBP-49247 Fab Light Chain Chains: D, F
Molecule details ›
Chains: D, F
Length: 218 amino acids
Theoretical weight: 23.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 73.495Å b: 141.905Å c: 186.122Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.232 0.264
Expression system: Homo sapiens

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