› 8uf8

Electron Microscopy
6.5Å resolution

Cryo-EM structure of alpha-Klotho

Released:
DOI: 10.2210/pdb8uf8/pdb
PDB entry 8uf8 coloured by chain, front view.
PDB entry 8uf8 coloured by chain, side view.
PDB entry 8uf8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.
Schnicker NJ, Xu Z, Amir M, Gakhar L, Huang CL
Sci Rep 15 543 (2025)
PMID: 39747283
Related structures: EMD-42186

Function and Biology Details

Reaction catalysed: 
A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-278850 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Klotho Chains: A, B
Molecule details ›
Chains: A, B
Length: 1012 amino acids
Theoretical weight: 116.32 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: Q9UEF7 (Residues: 1-1012; Coverage: 100%)
Gene name: KL
Sequence domains: Glycosyl hydrolase family 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.5Å
Relevant EMDB volumes: EMD-42186
Expression system: Mus musculus

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