› 8ufe

Electron Microscopy
3.68Å resolution

Multidrug efflux pump EfpA from mycobacterium smegmatis

Released:
DOI: 10.2210/pdb8ufe/pdb
PDB entry 8ufe coloured by chain, front view.
PDB entry 8ufe coloured by chain, side view.
PDB entry 8ufe coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis
Primary publication:
Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition.
Wang S, Wang K, Song K, Lai ZW, Li P, Li D, Sun Y, Mei Y, Xu C, Liao M
Nat Commun 15 7710 (2024)
PMID: 39231991
Related structures: EMD-42205

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-251199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative MFS-type transporter EfpA Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 48.4 KDa
Source organism: Mycolicibacterium smegmatis
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: A0A653FLF0 (Residues: 27-496; Coverage: 91%)
Gene names: BIN_B_04248, efpA_1
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand PTY 1 x PTY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.68Å
Relevant EMDB volumes: EMD-42205
Expression system: Mycolicibacterium smegmatis

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