› 8ugn

Electron Microscopy
2.7Å resolution

In-situ structure of typeO supercomplex in respiratory chain (composite)

Released:
DOI: 10.2210/pdb8ugn/pdb
PDB entry 8ugn coloured by chain, front view.
PDB entry 8ugn coloured by chain, side view.
PDB entry 8ugn coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
High-resolution in situ structures of mammalian respiratory supercomplexes.
Zheng W, Chai P, Zhu J, Zhang K
OpenAccess logo Nature (2024)
PMID: 38811722
Related structures: EMD-42230

Function and Biology Details

Reactions catalysed: 
NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
4 ferrocytochrome c + O(2) + 8 H(+)(Side 1) = 4 ferricytochrome c + 4 H(2)O(Side 2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 140-mer (preferred)
PDBe Complex ID:
PDB-CPX-245929 (preferred)
Entry contents:
68 distinct polypeptide molecules
Macromolecules (68 distinct):
NADH-ubiquinone oxidoreductase chain 3 Chains: 1A, 5A
Molecule details ›
Chains: 1A, 5A
Length: 115 amino acids
Theoretical weight: 13.03 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79880 (Residues: 1-115; Coverage: 100%)
Gene names: MT-ND3, MTND3, NADH3, ND3
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Chains: 1B, 5B
Molecule details ›
Chains: 1B, 5B
Length: 258 amino acids
Theoretical weight: 28.5 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VVS8 (Residues: 1-258; Coverage: 100%)
Gene name: NDUFS7
Sequence domains: NADH ubiquinone oxidoreductase, 20 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial Chains: 1C, 5C
Molecule details ›
Chains: 1C, 5C
Length: 264 amino acids
Theoretical weight: 30.15 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZNN4 (Residues: 1-264; Coverage: 100%)
Gene name: NDUFS3
Sequence domains: Respiratory-chain NADH dehydrogenase, 30 Kd subunit
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Chains: 1D, 5D
Molecule details ›
Chains: 1D, 5D
Length: 476 amino acids
Theoretical weight: 54.17 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0QM68 (Residues: 1-476; Coverage: 100%)
Gene name: NDUFS2
Sequence domains: Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial Chains: 1E, 5E
Molecule details ›
Chains: 1E, 5E
Length: 249 amino acids
Theoretical weight: 27.44 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VRV3 (Residues: 1-249; Coverage: 100%)
Gene name: NDUFV2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Chains: 1F, 5F
Molecule details ›
Chains: 1F, 5F
Length: 464 amino acids
Theoretical weight: 50.64 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SZP7 (Residues: 1-464; Coverage: 100%)
Gene name: NDUFV1
Sequence domains:
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial Chains: 1G, 5G
Molecule details ›
Chains: 1G, 5G
Length: 727 amino acids
Theoretical weight: 79.63 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287ARY3 (Residues: 14-740; Coverage: 98%)
Gene name: NDUFS1
Sequence domains:
NADH-ubiquinone oxidoreductase chain 1 Chains: 1H, 5H
Molecule details ›
Chains: 1H, 5H
Length: 318 amino acids
Theoretical weight: 35.62 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A0U1RS44 (Residues: 1-318; Coverage: 100%)
Gene names: MT-ND1, ND1
Sequence domains: NADH dehydrogenase
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Chains: 1I, 5I
Molecule details ›
Chains: 1I, 5I
Length: 239 amino acids
Theoretical weight: 27.14 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZUN9 (Residues: 1-239; Coverage: 100%)
Gene name: NDUFS8
Sequence domains: 4Fe-4S dicluster domain
NADH-ubiquinone oxidoreductase chain 6 Chains: 1J, 5J
Molecule details ›
Chains: 1J, 5J
Length: 175 amino acids
Theoretical weight: 19.02 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79882 (Residues: 1-175; Coverage: 100%)
Gene names: MT-ND6, MTND6, NADH6, ND6
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 6
NADH-ubiquinone oxidoreductase chain 4L Chains: 1K, 5K
Molecule details ›
Chains: 1K, 5K
Length: 98 amino acids
Theoretical weight: 10.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P56632 (Residues: 1-98; Coverage: 100%)
Gene names: MT-ND4L, MTND4L, NADH4L, ND4L
Sequence domains: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
NADH-ubiquinone oxidoreductase chain 5 Chains: 1L, 5L
Molecule details ›
Chains: 1L, 5L
Length: 606 amino acids
Theoretical weight: 68.72 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q9TDR1 (Residues: 1-606; Coverage: 100%)
Gene names: MT-ND5, MTND5, NADH5, ND5
Sequence domains:
NADH-ubiquinone oxidoreductase chain 4 Chains: 1M, 5M
Molecule details ›
Chains: 1M, 5M
Length: 459 amino acids
Theoretical weight: 51.89 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79881 (Residues: 1-459; Coverage: 100%)
Gene names: MT-ND4, MTND4, NADH4, ND4
Sequence domains:
NADH-ubiquinone oxidoreductase chain 2 Chains: 1N, 5N
Molecule details ›
Chains: 1N, 5N
Length: 347 amino acids
Theoretical weight: 39.11 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79875 (Residues: 1-347; Coverage: 100%)
Gene names: MT-ND2, MTND2, NADH2, ND2
Sequence domains:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Chains: 1O, 5O
Molecule details ›
Chains: 1O, 5O
Length: 357 amino acids
Theoretical weight: 40.48 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SIS9 (Residues: 1-357; Coverage: 100%)
Gene name: NDUFA10
Sequence domains: Deoxynucleoside kinase
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Chains: 1P, 5P
Molecule details ›
Chains: 1P, 5P
Length: 377 amino acids
Theoretical weight: 42.61 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1ULW2 (Residues: 1-377; Coverage: 100%)
Gene name: NDUFA9
Sequence domains: NAD dependent epimerase/dehydratase family
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Chains: 1Q, 5Q
Molecule details ›
Chains: 1Q, 5Q
Length: 175 amino acids
Theoretical weight: 19.75 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1SN37 (Residues: 1-175; Coverage: 100%)
Gene name: NDUFS4
Sequence domains: NADH dehydrogenase ubiquinone Fe-S protein 4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Chains: 1R, 5R
Molecule details ›
Chains: 1R, 5R
Length: 123 amino acids
Theoretical weight: 13.35 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1THU2 (Residues: 1-123; Coverage: 100%)
Gene name: NDUFS6
Sequence domains: Zinc-finger domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Chains: 1S, 5S
Molecule details ›
Chains: 1S, 5S
Length: 99 amino acids
Theoretical weight: 11.1 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1FN21 (Residues: 1-99; Coverage: 100%)
Gene name: NDUFA2
Sequence domains: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Acyl carrier protein Chains: 1T, 1U, 5T, 5U
Molecule details ›
Chains: 1T, 1U, 5T, 5U
Length: 156 amino acids
Theoretical weight: 17.34 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1KH26 (Residues: 1-156; Coverage: 100%)
Gene name: NDUFAB1
Sequence domains: Phosphopantetheine attachment site
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Chains: 1V, 5V
Molecule details ›
Chains: 1V, 5V
Length: 116 amino acids
Theoretical weight: 13.32 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0UWW0 (Residues: 1-116; Coverage: 99%)
Sequence domains: ETC complex I subunit conserved region
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 Chains: 1W, 5W
Molecule details ›
Chains: 1W, 5W
Length: 128 amino acids
Theoretical weight: 14.95 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A480VKQ8 (Residues: 1-128; Coverage: 100%)
Sequence domains: Complex 1 protein (LYR family)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 Chains: 1X, 5X
Molecule details ›
Chains: 1X, 5X
Length: 172 amino acids
Theoretical weight: 20.06 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0K6B5 (Residues: 77-248; Coverage: 69%)
Sequence domains: CHCH domain
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 Chains: 1Y, 5Y
Molecule details ›
Chains: 1Y, 5Y
Length: 141 amino acids
Theoretical weight: 14.69 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: I3LGM4 (Residues: 1-141; Coverage: 100%)
Gene name: NDUFA11
Sequence domains: Tim17/Tim22/Tim23/Pmp24 family
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Chains: 1Z, 5Z
Molecule details ›
Chains: 1Z, 5Z
Length: 144 amino acids
Theoretical weight: 16.91 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0K655 (Residues: 1-144; Coverage: 100%)
Gene name: NDUFA13
Sequence domains: GRIM-19 protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Chains: 1a, 5a
Molecule details ›
Chains: 1a, 5a
Length: 70 amino acids
Theoretical weight: 8.03 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0TJQ4 (Residues: 92-161; Coverage: 44%)
Sequence domains: NADH-ubiquinone oxidoreductase MWFE subunit
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Chains: 1b, 5b
Molecule details ›
Chains: 1b, 5b
Length: 84 amino acids
Theoretical weight: 9.23 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VQ42 (Residues: 1-84; Coverage: 100%)
Gene name: NDUFA3
Sequence domains: NADH dehydrogenase 1 alpha subcomplex subunit 3
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Chains: 1c, 5c
Molecule details ›
Chains: 1c, 5c
Length: 76 amino acids
Theoretical weight: 8.66 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1EYQ2 (Residues: 77-152; Coverage: 50%)
Sequence domains: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
NADH dehydrogenase [ubiquinone] 1 subunit C2 Chains: 1d, 5d
Molecule details ›
Chains: 1d, 5d
Length: 122 amino acids
Theoretical weight: 14.33 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A480JRW3 (Residues: 1-122; Coverage: 100%)
Gene name: NDUFC2
Sequence domains: NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Chains: 1e, 5e
Molecule details ›
Chains: 1e, 5e
Length: 106 amino acids
Theoretical weight: 12.51 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VX77 (Residues: 1-106; Coverage: 100%)
Gene name: NDUFS5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 Chains: 1f, 5f
Molecule details ›
Chains: 1f, 5f
Length: 135 amino acids
Theoretical weight: 15.37 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1IZ33 (Residues: 1-106; Coverage: 100%)
Sequence domains: MNLL subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Chains: 1g, 5g
Molecule details ›
Chains: 1g, 5g
Length: 154 amino acids
Theoretical weight: 17.38 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1EYI7 (Residues: 1-154; Coverage: 100%)
Sequence domains: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial Chains: 1h, 5h
Molecule details ›
Chains: 1h, 5h
Length: 189 amino acids
Theoretical weight: 21.59 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SGC6 (Residues: 1-189; Coverage: 100%)
Gene name: NDUFB5
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Chains: 1i, 5i
Molecule details ›
Chains: 1i, 5i
Length: 128 amino acids
Theoretical weight: 15.65 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1UIV8 (Residues: 1-128; Coverage: 100%)
Gene name: NDUFB6
Sequence domains: NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Chains: 1j, 5j
Molecule details ›
Chains: 1j, 5j
Length: 105 amino acids
Theoretical weight: 11.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1G9F4 (Residues: 1-105; Coverage: 100%)
Gene name: NDUFB2
Sequence domains: NADH dehydrogenase 1 beta subcomplex subunit 2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Chains: 1k, 5k
Molecule details ›
Chains: 1k, 5k
Length: 98 amino acids
Theoretical weight: 11.13 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1VD84 (Residues: 1-98; Coverage: 100%)
Gene name: NDUFB3
Sequence domains: NADH-ubiquinone oxidoreductase B12 subunit family
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Chains: 1l, 5l
Molecule details ›
Chains: 1l, 5l
Length: 186 amino acids
Theoretical weight: 21.66 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: B8Y651 (Residues: 1-186; Coverage: 100%)
Gene name: NDUFB8
Sequence domains: NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Chains: 1m, 5m
Molecule details ›
Chains: 1m, 5m
Length: 129 amino acids
Theoretical weight: 15.12 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1T6M0 (Residues: 1-129; Coverage: 100%)
Gene name: NDUFB4
Sequence domains: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 Chains: 1n, 5n
Molecule details ›
Chains: 1n, 5n
Length: 179 amino acids
Theoretical weight: 21.86 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: K7GSE5 (Residues: 43-221; Coverage: 81%)
Gene name: NDUFB9
Sequence domains: Complex 1 protein (LYR family)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Chains: 1o, 5o
Molecule details ›
Chains: 1o, 5o
Length: 137 amino acids
Theoretical weight: 16.57 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SCH1 (Residues: 2-137; Coverage: 99%)
Gene name: NDUFB7
Sequence domains: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Chains: 1p, 5p
Molecule details ›
Chains: 1p, 5p
Length: 176 amino acids
Theoretical weight: 20.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0R7A9 (Residues: 124-299; Coverage: 59%)
Sequence domains: NADH-ubiquinone oxidoreductase subunit 10
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Chains: 1q, 5q
Molecule details ›
Chains: 1q, 5q
Length: 145 amino acids
Theoretical weight: 17.16 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SQP4 (Residues: 1-145; Coverage: 100%)
Gene name: NDUFA12
Sequence domains: NADH ubiquinone oxidoreductase subunit NDUFA12
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Chains: 1r, 5r
Molecule details ›
Chains: 1r, 5r
Length: 113 amino acids
Theoretical weight: 12.65 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8W4F7N8 (Residues: 1-113; Coverage: 100%)
Gene name: NDUFA7
Sequence domains: NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
NADH:ubiquinone oxidoreductase subunit V3 Chains: 1s, 5s
Molecule details ›
Chains: 1s, 5s
Length: 471 amino acids
Theoretical weight: 48.22 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TE42 (Residues: 1-471; Coverage: 100%)
Gene name: NDUFV3
Sequence domains: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Cytochrome b-c1 complex subunit 1, mitochondrial Chains: 3A, 3N
Molecule details ›
Chains: 3A, 3N
Length: 480 amino acids
Theoretical weight: 52.76 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0PK14 (Residues: 1-480; Coverage: 100%)
Gene name: LOC100156879
Sequence domains:
Ubiquinol-cytochrome c reductase core protein 2 Chains: 3B, 3O
Molecule details ›
Chains: 3B, 3O
Length: 453 amino acids
Theoretical weight: 48.26 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1RPD2 (Residues: 1-453; Coverage: 100%)
Gene names: LOC100524613, UQCRC2
Sequence domains:
Cytochrome b Chains: 3C, 3P
Molecule details ›
Chains: 3C, 3P
Length: 379 amino acids
Theoretical weight: 42.84 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q1HBG9 (Residues: 1-379; Coverage: 100%)
Gene names: CYTB, CytB, MT-CYB, cytb
Sequence domains:
Cytochrome c domain-containing protein Chains: 3D, 3Q
Molecule details ›
Chains: 3D, 3Q
Length: 326 amino acids
Theoretical weight: 35.49 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AZF9 (Residues: 1-326; Coverage: 100%)
Gene name: CYC1
Sequence domains: Cytochrome C1 family
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: 3E, 3I, 3R, 3V
Molecule details ›
Chains: 3E, 3I, 3R, 3V
Length: 274 amino acids
Theoretical weight: 29.54 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TWD8 (Residues: 1-274; Coverage: 100%)
Gene name: LOC100522678
Sequence domains:
Cytochrome b-c1 complex subunit 7 Chains: 3F, 3S
Molecule details ›
Chains: 3F, 3S
Length: 111 amino acids
Theoretical weight: 13.59 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A286ZPR8 (Residues: 1-111; Coverage: 100%)
Gene name: UQCRB
Sequence domains: Ubiquinol-cytochrome C reductase complex 14kD subunit
Cytochrome b-c1 complex subunit 8 Chains: 3G, 3T
Molecule details ›
Chains: 3G, 3T
Length: 82 amino acids
Theoretical weight: 9.78 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D0SHY6 (Residues: 1-82; Coverage: 100%)
Gene name: LOC100524308
Sequence domains: UcrQ family
Cytochrome b-c1 complex subunit 6 Chains: 3H, 3U
Molecule details ›
Chains: 3H, 3U
Length: 91 amino acids
Theoretical weight: 10.69 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A8D1JI21 (Residues: 1-91; Coverage: 100%)
Gene name: LOC100524873
Sequence domains: Ubiquinol-cytochrome C reductase hinge protein
Complex III subunit 9 Chains: 3J, 3W
Molecule details ›
Chains: 3J, 3W
Length: 64 amino acids
Theoretical weight: 7.28 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q2EN79 (Residues: 1-64; Coverage: 100%)
Gene name: UQCR10
Sequence domains: Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
Cytochrome b-c1 complex subunit 10 Chains: 3X, 3Y
Molecule details ›
Chains: 3X, 3Y
Length: 56 amino acids
Theoretical weight: 6.56 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SDI2 (Residues: 1-56; Coverage: 100%)
Gene name: UQCR11
Sequence domains: Ubiquinol-cytochrome C reductase complex, 6.4kD protein
Cytochrome c oxidase subunit 1 Chains: 4A, 8A
Molecule details ›
Chains: 4A, 8A
Length: 514 amino acids
Theoretical weight: 57.02 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: O79876 (Residues: 1-514; Coverage: 100%)
Gene names: COI, COXI, MT-CO1, MTCO1
Sequence domains: Cytochrome C and Quinol oxidase polypeptide I
Cytochrome c oxidase subunit 2 Chains: 4B, 8B
Molecule details ›
Chains: 4B, 8B
Length: 229 amino acids
Theoretical weight: 26.29 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q69GF7 (Residues: 1-229; Coverage: 100%)
Gene names: COII, COX2, MT-CO2
Sequence domains:
Cytochrome c oxidase subunit 3 Chains: 4C, 8C
Molecule details ›
Chains: 4C, 8C
Length: 261 amino acids
Theoretical weight: 29.75 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q35916 (Residues: 1-261; Coverage: 100%)
Gene names: COIII, COXIII, MT-CO3, MTCO3
Sequence domains: Cytochrome c oxidase subunit III
Cytochrome c oxidase subunit 4 Chains: 4D, 8D
Molecule details ›
Chains: 4D, 8D
Length: 169 amino acids
Theoretical weight: 19.67 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1T8J9 (Residues: 1-169; Coverage: 100%)
Gene name: LOC100624067
Sequence domains: Cytochrome c oxidase subunit IV
Cytochrome c oxidase subunit 5A, mitochondrial Chains: 4E, 8E
Molecule details ›
Chains: 4E, 8E
Length: 152 amino acids
Theoretical weight: 16.77 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: F1SJ34 (Residues: 1-152; Coverage: 100%)
Gene name: COX5A
Sequence domains: Cytochrome c oxidase subunit Va
Cytochrome c oxidase subunit 5B, mitochondrial Chains: 4F, 8F
Molecule details ›
Chains: 4F, 8F
Length: 128 amino acids
Theoretical weight: 13.66 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q5S3G4 (Residues: 1-128; Coverage: 99%)
Gene name: COX5B
Sequence domains: Cytochrome c oxidase subunit Vb
Cytochrome c oxidase subunit Chains: 4G, 8G
Molecule details ›
Chains: 4G, 8G
Length: 97 amino acids
Theoretical weight: 10.88 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287AEB7 (Residues: 1-97; Coverage: 100%)
Gene names: COX6A2, LOC100626250
Sequence domains: Cytochrome c oxidase subunit VIa
Cytochrome c oxidase subunit Chains: 4H, 8H
Molecule details ›
Chains: 4H, 8H
Length: 86 amino acids
Theoretical weight: 10.2 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A1XQT1 (Residues: 1-86; Coverage: 100%)
Gene name: COX6B
Sequence domains: Cytochrome oxidase c subunit VIb
Cytochrome c oxidase subunit 6C Chains: 4I, 8I
Molecule details ›
Chains: 4I, 8I
Length: 75 amino acids
Theoretical weight: 8.62 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A4X1TXH1 (Residues: 1-75; Coverage: 100%)
Gene name: COX6C
Sequence domains: Cytochrome c oxidase subunit VIc
Cytochrome c oxidase subunit 7A1, mitochondrial Chains: 4J, 8J
Molecule details ›
Chains: 4J, 8J
Length: 80 amino acids
Theoretical weight: 9.03 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q8SPJ9 (Residues: 1-80; Coverage: 100%)
Gene name: COX7A1
Sequence domains: Cytochrome c oxidase subunit VII
Cytochrome c oxidase subunit 7B, mitochondrial Chains: 4K, 8K
Molecule details ›
Chains: 4K, 8K
Length: 80 amino acids
Theoretical weight: 9.17 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A0A287BJ57 (Residues: 1-80; Coverage: 100%)
Gene name: COX7B
Sequence domains: Cytochrome C oxidase chain VIIB
Cytochrome c oxidase subunit 7C, mitochondrial Chains: 4L, 8L
Molecule details ›
Chains: 4L, 8L
Length: 63 amino acids
Theoretical weight: 7.36 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q1W0Y2 (Residues: 1-63; Coverage: 100%)
Gene names: COX7C, COX7C1
Sequence domains: Cytochrome c oxidase subunit VIIc
Cytochrome c oxidase subunit 8 Chains: 4M, 8M
Molecule details ›
Chains: 4M, 8M
Length: 70 amino acids
Theoretical weight: 7.62 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A1XQT4 (Residues: 1-70; Coverage: 100%)
Gene name: COX8H
Sequence domains: Cytochrome oxidase c subunit VIII
Mitochondrial NDUFA4 Chains: 4N, 8N
Molecule details ›
Chains: 4N, 8N
Length: 82 amino acids
Theoretical weight: 9.32 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A1XQS3 (Residues: 1-82; Coverage: 100%)
Gene name: NDUFA4
Sequence domains: NADH-ubiquinone reductase complex 1 MLRQ subunit

Ligands and Environments

25 bound ligands:
Ligand PC1 31 x PC1
Ligand SF4 12 x SF4
Ligand FES 6 x FES
Ligand FMN 2 x FMN
Ligand K 2 x K
Ligand CDL 26 x CDL
Ligand AYA 2 x AYA
Ligand 3PE 47 x 3PE
Ligand GTP 2 x GTP
Ligand MG 4 x MG
Ligand NDP 2 x NDP
Ligand ZN 4 x ZN
Ligand EHZ 4 x EHZ
Ligand AME 2 x AME
Ligand MYR 2 x MYR
Ligand HEM 4 x HEM
Ligand HEC 2 x HEC
Ligand PGV 30 x PGV
Ligand HEA 4 x HEA
Ligand CU 2 x CU
Ligand NA 2 x NA
Ligand PSC 2 x PSC
Ligand CUA 2 x CUA
Ligand PEK 4 x PEK
Ligand PO4 2 x PO4
2 modified residues:
Ligand FME 16 x FME
Ligand SAC 2 x SAC

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-42230

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