8ui9

Electron Microscopy
3.5Å resolution

Cryo-EM map of human clamp-clamp loader ATAD5-RFC-cracked PCNA complex in intermediate state 2

Released:
Source organism: Homo sapiens
Related structures: EMD-42289

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273171 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
ATPase family AAA domain-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 1032 amino acids
Theoretical weight: 116.42 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q96QE3 (Residues: 813-1844; Coverage: 56%)
Gene names: ATAD5, C17orf41, Elg1, FRAG1
Sequence domains: ATPase family associated with various cellular activities (AAA)
Replication factor C subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 354 amino acids
Theoretical weight: 39.2 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P35250 (Residues: 1-354; Coverage: 100%)
Gene name: RFC2
Sequence domains:
Replication factor C subunit 5 Chain: C
Replication factor C subunit 4 Chain: D
Replication factor C subunit 3 Chain: E
Proliferating cell nuclear antigen Chains: F, G, H

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-42289
Expression system: Insect cell expression vector pTIE1