› 8uo8

Electron Microscopy
3.2Å resolution

Structure of synaptic vesicle protein 2B with padsevonil

Released:
DOI: 10.2210/pdb8uo8/pdb
PDB entry 8uo8 coloured by chain, front view.
PDB entry 8uo8 coloured by chain, side view.
PDB entry 8uo8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Mittal A, Martin MF, Levin EJ, Adams C, Yang M, Provins L, Hall A, Procter M, Ledecq M, Hillisch A, Wolff C, Gillard M, Horanyi PS, Coleman JA
Nat Struct Mol Biol (2024)
PMID: 38898101
Related structures: EMD-42430

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptic vesicle glycoprotein 2B Chain: A
Molecule details ›
Chain: A
Length: 683 amino acids
Theoretical weight: 77.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7L1I2 (Residues: 1-683; Coverage: 100%)
Gene names: KIAA0735, SV2B
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand NAG 3 x NAG
Ligand X3U 1 x X3U
Ligand PS1 1 x PS1
Ligand 9Z9 2 x 9Z9
Ligand 43Y 1 x 43Y
Ligand Y01 1 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-42430
Expression system: Homo sapiens

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