› 8uqv

Electron Microscopy
3.6Å resolution

Trehalose Synthase (TreS) of Mycobacterium tuberculosis in complex with 6-TreAz compound

Released:
DOI: 10.2210/pdb8uqv/pdb
PDB entry 8uqv coloured by chain, front view.
PDB entry 8uqv coloured by chain, side view.
PDB entry 8uqv coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift.
Kalera K, Liu R, Lim J, Pathirage R, Swanson DH, Johnson UG, Stothard AI, Lee JJ, Poston AW, Woodruff PJ, Ronning DR, Eoh H, Swarts BM
ACS Infect Dis (2024)
PMID: 38485491
Related structures: EMD-42478

Function and Biology Details

Reactions catalysed: 
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units
Maltose = alpha,alpha-trehalose
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245804 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trehalose synthase/amylase TreS Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 575 amino acids
Theoretical weight: 65.79 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WQ19 (Residues: 12-586; Coverage: 96%)
Gene names: Rv0126, treS
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand GLC 4 x GLC
Ligand XVC 4 x XVC
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-42478
Expression system: Escherichia coli

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