› 8utf

Electron Microscopy
2.73Å resolution

Structure of the Measles virus Fusion protein in the post-fusion conformation

Released:
DOI: 10.2210/pdb8utf/pdb
PDB entry 8utf coloured by chain, front view.
PDB entry 8utf coloured by chain, side view.
PDB entry 8utf coloured by chain, top view.
Source organism: Measles virus strain Ichinose-B95a
Primary publication:
A neutralizing antibody prevents postfusion transition of measles virus fusion protein.
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science 384 eadm8693 (2024)
PMID: 38935733
Related structures: EMD-42539

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181226 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fusion glycoprotein F2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 112 amino acids
Theoretical weight: 12.5 KDa
Source organism: Measles virus strain Ichinose-B95a
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q786F3 (Residues: 1-112; Coverage: 17%)
Gene name: F
Fusion glycoprotein F1 Chains: a, b, c
Molecule details ›
Chains: a, b, c
Length: 420 amino acids
Theoretical weight: 44.9 KDa
Source organism: Measles virus strain Ichinose-B95a
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q786F3 (Residues: 113-495; Coverage: 73%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

1 bound ligand:
Ligand NAG 9 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.73Å
Relevant EMDB volumes: EMD-42539
Expression system: Drosophila melanogaster

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