› 8uue

Electron Microscopy
3.96Å resolution

Glycine-bound GluN1a-3A LBD heterotetramer (local refinement)

Released:
DOI: 10.2210/pdb8uue/pdb
PDB entry 8uue coloured by chain, front view.
PDB entry 8uue coloured by chain, side view.
PDB entry 8uue coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Michalski K, Furukawa H
OpenAccess logo Sci Adv 10 eadl5952 (2024)
PMID: 38598639
Related structures: EMD-42580

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274455 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 404 amino acids
Theoretical weight: 45.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 395-798; Coverage: 44%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Glutamate receptor ionotropic, NMDA 3A Chains: B, D
Molecule details ›
Chains: B, D
Length: 403 amino acids
Theoretical weight: 45.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TCU5 (Residues: 511-913; Coverage: 37%)
Gene names: GRIN3A, KIAA1973
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.96Å
Relevant EMDB volumes: EMD-42580
Expression system: Spodoptera frugiperda

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Citations

3 citation in other articles

Molecular mechanism of ligand gating and opening of NMDA receptor.
Chou et al. (2024)
2 more