› 8uul

Electron Microscopy
3.2Å resolution

Prototypic SARS-CoV-2 spike (containing K417) in the closed conformation

Released:
DOI: 10.2210/pdb8uul/pdb
PDB entry 8uul coloured by chain, front view.
PDB entry 8uul coloured by chain, side view.
PDB entry 8uul coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein.
Geng Q, Wan Y, Hsueh FC, Shang J, Ye G, Bu F, Herbst M, Wilkens R, Liu B, Li F
OpenAccess logo Elife 12 (2023)
PMID: 37991488
Related structures: EMD-42589

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1211 amino acids
Theoretical weight: 134.14 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1211; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 19 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-42589
Expression system: Homo sapiens

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