8uxq

Electron Microscopy
6.3Å resolution

Structure of Heterochromatin Protein 1 (HP1) alpha in complex with an H2A.Z nucleosome

Released:
Entry authors: Tan D, Sokolova V
Related structures: EMD-42774

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-270852 (preferred)
Entry contents:
5 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (7 distinct):
Chromobox protein homolog 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 195 amino acids
Theoretical weight: 22.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45973 (Residues: 2-191; Coverage: 100%)
Gene names: CBX5, HP1A
Sequence domains:
Histone H3.2 Chains: E, K
Molecule details ›
Chains: E, K
Length: 135 amino acids
Theoretical weight: 15.3 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P84233 (Residues: 2-136; Coverage: 99%)
Sequence domains: Core histone H2A/H2B/H3/H4
Histone H4 Chains: F, L
Histone H2A.Z Chains: G, M
Histone H2B 1.1 Chains: H, N
DNA Widom601 (208bp) strand1 Chain: I
DNA Widom601 (208bp) strand2 Chain: J

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.3Å
Relevant EMDB volumes: EMD-42774
Expression system: Escherichia coli