› 8uxs

X-ray diffraction
2Å resolution

KLHDC2 ubiquitin ligase in complex with a novel small-molecule

Released:
DOI: 10.2210/pdb8uxs/pdb
PDB entry 8uxs coloured by chain, front view.
PDB entry 8uxs coloured by chain, side view.
PDB entry 8uxs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rusnac DV, Zheng N

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-221498 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch domain-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q9Y2U9 (Residues: 22-362; Coverage: 84%)
Gene names: HCA33, KLHDC2
Sequence domains: Galactose oxidase, central domain

Ligands and Environments

1 bound ligand:
Ligand XU8 2 x XU8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21
Unit cell:
a: 44.381Å b: 88.165Å c: 88.512Å
α: 90° β: 104.39° γ: 90°
R-values:
R R work R free
0.167 0.166 0.202
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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