› 8uyf

Electron Microscopy
2.75Å resolution

Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer

Released:
DOI: 10.2210/pdb8uyf/pdb
PDB entry 8uyf coloured by chain, front view.
PDB entry 8uyf coloured by chain, side view.
PDB entry 8uyf coloured by chain, top view.
Source organism: Pediculus humanus corporis
Primary publication:
Interaction of PINK1 with nucleotides and kinetin.
Gan ZY, Callegari S, Nguyen TN, Kirk NS, Leis A, Lazarou M, Dewson G, Komander D
OpenAccess logo Sci Adv 10 eadj7408 (2024)
PMID: 38241364
Related structures: EMD-42804

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122712 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Pink1, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 463 amino acids
Theoretical weight: 53.05 KDa
Source organism: Pediculus humanus corporis
Expression system: Escherichia coli
UniProt:
  • Canonical: E0W1I1 (Residues: 115-575; Coverage: 80%)
Gene names: Phum_PHUM577390, Pink1
Sequence domains: Protein kinase domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
Resolution: 2.75Å
Relevant EMDB volumes: EMD-42804
Expression system: Escherichia coli

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