› 8uyn

X-ray diffraction
2Å resolution

Fundamental Characterization of Chelated and Crystallized Actinium in a Macromolecular Host

Released:
DOI: 10.2210/pdb8uyn/pdb
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PDB entry 8uyn coloured by chain, front view.
PDB entry 8uyn coloured by chain, side view.
PDB entry 8uyn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Actinium chelation and crystallization in a macromolecular scaffold.
Wacker JN, Woods JJ, Rupert PB, Peterson A, Allaire M, Lukens WW, Gaiser AN, Minasian SG, Strong RK, Abergel RJ
Nat Commun 15 5741 (2024)
PMID: 39009580

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil gelatinase-associated lipocalin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 178 amino acids
Theoretical weight: 20.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80188 (Residues: 21-198; Coverage: 100%)
Gene names: HNL, LCN2, NGAL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family

Ligands and Environments

4 bound ligands:
Ligand LA 3 x LA
Ligand 4OL 3 x 4OL
Ligand SO4 1 x SO4
Ligand PIN 1 x PIN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 116.148Å b: 116.148Å c: 117.562Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.227
Expression system: Escherichia coli

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