› 8uyo

Electron Microscopy
3.3Å resolution

Structure of a recombinant human PNMA2 capsid

Released:
DOI: 10.2210/pdb8uyo/pdb
PDB entry 8uyo coloured by chain, front view.
PDB entry 8uyo coloured by chain, side view.
PDB entry 8uyo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery.
Madigan V, Zhang Y, Raghavan R, Wilkinson ME, Faure G, Puccio E, Segel M, Lash B, Macrae RK, Zhang F
Proc Natl Acad Sci U S A 121 e2307812120 (2024)
PMID: 38437549
Related structures: EMD-42812

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242001 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Paraneoplastic antigen Ma2 Chain: 1
Molecule details ›
Chain: 1
Length: 364 amino acids
Theoretical weight: 41.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UL42 (Residues: 1-364; Coverage: 100%)
Gene names: KIAA0883, MA2, PNMA2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-42812
Expression system: Escherichia coli

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