› 8v1f

X-ray diffraction
2.19Å resolution

TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol

Released:
DOI: 10.2210/pdb8v1f/pdb
PDB entry 8v1f coloured by chain, front view.
PDB entry 8v1f coloured by chain, side view.
PDB entry 8v1f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fraser BJ, Dong A, Kutera M, Seitova A, Li Y, Hutchinson A, Edwards A, Benard F, Halabelian L, Arrowsmith C, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236242 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Transmembrane protease serine 2 non-catalytic chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 110 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15393 (Residues: 148-255; Coverage: 22%)
Gene names: PRSS10, TMPRSS2
Sequence domains: Scavenger receptor cysteine-rich domain
Transmembrane protease serine 2 catalytic chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 249 amino acids
Theoretical weight: 27.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15393 (Residues: 256-492; Coverage: 48%)
Gene names: PRSS10, TMPRSS2
Sequence domains: Trypsin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
7 bound ligands:
Ligand TAM 4 x TAM
Ligand UNX 3 x UNX
Ligand EDO 20 x EDO
Ligand 7R8 2 x 7R8
Ligand PEG 1 x PEG
Ligand CIT 2 x CIT
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 118.939Å b: 172.573Å c: 83.297Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.172 0.223
Expression system: Spodoptera frugiperda

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