› 8v1l

X-ray diffraction
2.68Å resolution

Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule

Released:
DOI: 10.2210/pdb8v1l/pdb
PDB entry 8v1l coloured by chain, front view.
PDB entry 8v1l coloured by chain, side view.
PDB entry 8v1l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of small molecule inhibitors of G3BP-driven stress granule formation.
Freibaum BD, Messing J, Nakamura H, Yurtsever U, Wu J, Kim HJ, Hixon J, Lemieux RM, Duffner J, Huynh W, Wong K, White M, Lee C, Meyers RE, Parker R, Taylor JP
J Cell Biol 223 (2024)
PMID: 38284934

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras GTPase-activating protein-binding protein 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 139 amino acids
Theoretical weight: 15.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13283 (Residues: 1-139; Coverage: 30%)
Gene names: G3BP, G3BP1
Sequence domains: Nuclear transport factor 2 (NTF2) domain

Ligands and Environments

1 bound ligand:
Ligand Y9M 6 x Y9M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P21
Unit cell:
a: 52.17Å b: 84.69Å c: 102.15Å
α: 90° β: 91.26° γ: 90°
R-values:
R R work R free
0.281 0.276 0.395
Expression system: Escherichia coli

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