8v2s

Electron Microscopy
2.72Å resolution

CHMP1B/IST1 dsDNA bound copolymer

Released:
Source organism: Homo sapiens
Entry authors: Talledge N, Laughlin TG, Alian A
Related structures: EMD-42932

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 192-mer (preferred)
PDBe Complex ID:
PDB-CPX-281632 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Charged multivesicular body protein 1b Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7LBR1 (Residues: 1-199; Coverage: 100%)
Gene names: C18orf2, CHMP1B
Sequence domains: Snf7
IST1 homolog Chain: B
Molecule details ›
Chain: B
Length: 364 amino acids
Theoretical weight: 39.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53990 (Residues: 1-364; Coverage: 100%)
Gene names: IST1, KIAA0174
Sequence domains: Regulator of Vps4 activity in the MVB pathway

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.72Å
Relevant EMDB volumes: EMD-42932
Expression system: Escherichia coli BL21(DE3)