› 8v52

X-ray diffraction
2.5Å resolution

Crystal structure of 2A10 Fab bound to Human TGF-beta3

Released:
DOI: 10.2210/pdb8v52/pdb
PDB entry 8v52 coloured by chain, front view.
PDB entry 8v52 coloured by chain, side view.
PDB entry 8v52 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Isoform-selective TGF-β3 inhibition for systemic sclerosis.
Sun T, Vander Heiden JA, Gao X, Yin J, Uttarwar S, Liang WC, Jia G, Yadav R, Huang Z, Mitra M, Halpern W, Bender HS, Brightbill HD, Wu Y, Lupardus P, Ramalingam T, Arron JR
Med 5 132-147.e7 (2024)
PMID: 38272035

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242865 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Transforming growth factor beta-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P10600 (Residues: 301-412; Coverage: 29%)
Gene name: TGFB3
Sequence domains: Transforming growth factor beta like domain
2A10 Fab Light chain Chains: C, E
Molecule details ›
Chains: C, E
Length: 218 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
2A10 Fab Heavy Chain Chains: D, F
Molecule details ›
Chains: D, F
Length: 227 amino acids
Theoretical weight: 24.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Unit cell:
a: 133.94Å b: 47.2Å c: 200.83Å
α: 90° β: 101.68° γ: 90°
R-values:
R R work R free
0.223 0.221 0.269
Expression system: Cricetulus griseus

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