› 8v5a

Electron Microscopy
3Å resolution

Prefusion-stabilized Respirovirus type 3 Fusion protein

Released:
DOI: 10.2210/pdb8v5a/pdb
PDB entry 8v5a coloured by chain, front view.
PDB entry 8v5a coloured by chain, side view.
PDB entry 8v5a coloured by chain, top view.
Source organisms:
Primary publication:
Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein.
Langedijk JPM, Cox F, Johnson NV, van Overveld D, Le L, van den Hoogen W, Voorzaat R, Zahn R, van der Fits L, Juraszek J, McLellan JS, Bakkers MJG
OpenAccess logo Nat Commun 15 4629 (2024)
PMID: 38821950
Related structures: EMD-42981

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-268447 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 491 amino acids
Theoretical weight: 54.15 KDa
Source organism: Human respirovirus 3
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A023PFZ0 (Residues: 1-486; Coverage: 90%)
Gene names: AZ69_44281gpF, AZ69_44294gpF, AZ69_44297gpF, AZ69_44301gpF, AZ69_44304gpF, AZ69_44305gpF, AZ69_44306gpF, AZ69_44316gpF, AZ69_44327gpF, AZ69_44331gpF, F, PIV3gp6
Sequence domains: Fusion glycoprotein F0
Camelid nanobody 4C06 Chains: U, W, Y
Molecule details ›
Chains: U, W, Y
Length: 117 amino acids
Theoretical weight: 12.49 KDa
Source organism: Lama glama
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-42981
Expression systems:
  • Homo sapiens
  • Escherichia coli

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