PDB 8v6i structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reactions catalysed:

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

SsDNA + n NTP = ssDNA/pppN(pN)(n-1) hybrid + (n-1) diphosphate

Biochemical function:

DNA binding

Biological process:

DNA replication

Cellular component:

alpha DNA polymerase:primase complex

Structure analysis Details

Assembly composition:

hetero hexamer (preferred)

PDBe Complex ID:

PDB-CPX-236673 (preferred)

Entry contents:

4 distinct polypeptide molecules
1 distinct DNA molecule
1 distinct DNA/RNA hybrid molecule

Macromolecules (6 distinct):

DNA polymerase alpha catalytic subunit Chain: A

Molecule details ›

Chain: A
Length: 1127 amino acids
Theoretical weight: 129.01 KDa
Source organism: Xenopus laevis
Expression system: Spodoptera frugiperda
UniProt:

Canonical: Q9DE46 (Residues: 335-1458; Coverage: 77%)

Gene names: pola, pola1
Sequence domains:

DNA polymerase alpha subunit B Chain: B

Molecule details ›

Chain: B
Length: 601 amino acids
Theoretical weight: 67.19 KDa
Source organism: Xenopus laevis
Expression system: Spodoptera frugiperda
UniProt:

Canonical: Q6DCZ1 (Residues: 1-598; Coverage: 100%)

Gene names: MGC80532, pola2, pola2.L
Sequence domains:

DNA primase large subunit Chain: C

Molecule details ›

Chain: C
Length: 513 amino acids
Theoretical weight: 59.67 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:

Canonical: A0A1L8G3G3 (Residues: 1-513; Coverage: 100%)

Gene name: prim2.S
Sequence domains: Eukaryotic and archaeal DNA primase, large subunit

DNA primase Chain: D

Molecule details ›

Chain: D
Length: 423 amino acids
Theoretical weight: 49.36 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt: