› 8v6n

Electron Microscopy
2.59Å resolution

Open-state cryo-EM structure of human TRPV3 in presence of 2-APB in cNW30 nanodiscs

Released:
DOI: 10.2210/pdb8v6n/pdb
PDB entry 8v6n coloured by chain, front view.
PDB entry 8v6n coloured by chain, side view.
PDB entry 8v6n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Nadezhdin KD, Neuberger A, Khosrof LS, Talyzina IA, Khau J, Yelshanskaya MV, Sobolevsky AI
Sci Adv 10 eadn2453 (2024)
PMID: 38691614
Related structures: EMD-42997

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 92.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NET8 (Residues: 1-759, 760-790; Coverage: 100%)
Gene name: TRPV3
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand POV 20 x POV
Ligand ACD 4 x ACD
Ligand FZ4 8 x FZ4
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.59Å
Relevant EMDB volumes: EMD-42997
Expression system: Homo sapiens

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