8v6u

Electron Microscopy
3Å resolution

5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-279888 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
5-hydroxytryptamine receptor 2A Chain: A
Molecule details ›
Chain: A
Length: 339 amino acids
Theoretical weight: 38.27 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P28223 (Residues: 66-404; Coverage: 72%)
Gene names: HTR2, HTR2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)
G protein alpha-subunit q (Gi2-mini-Gq chimera) Chain: B
Molecule details ›
Chain: B
Length: 246 amino acids
Theoretical weight: 28.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: C
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: D
single-chain variable fragment 16 (scFv16) Chain: E

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-42999
Expression system: Spodoptera frugiperda