› 8v8z

X-ray diffraction
2.01Å resolution

Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3473329

Released:
DOI: 10.2210/pdb8v8z/pdb
PDB entry 8v8z coloured by chain, front view.
PDB entry 8v8z coloured by chain, side view.
PDB entry 8v8z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Diaz N, Perez C, Escribano AM, Sanz G, Priego J, Lafuente C, Barberis M, Calle L, Espinosa JF, Priest BT, Zhang HY, Nosie AK, Haas JV, Cannady E, Borel A, Schultze AE, Sauder JM, Hendle J, Weichert K, Nicholls SJ, Michael LF
OpenAccess logo Nature 629 945-950 (2024)
PMID: 38720069

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein(a) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 94 amino acids
Theoretical weight: 10.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08519 (Residues: 1377-1470; Coverage: 5%)
Gene name: LPA
Sequence domains: Kringle domain

Ligands and Environments

1 bound ligand:
Ligand A1AAK 1 x A1AAK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 37.755Å b: 75.179Å c: 93.314Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.26
Expression system: Escherichia coli

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