› 8v9a

X-ray diffraction
1.67Å resolution

GII.NA1 Loreto 1257 norovirus protruding domain

Released:
DOI: 10.2210/pdb8v9a/pdb
PDB entry 8v9a coloured by chain, front view.
PDB entry 8v9a coloured by chain, side view.
PDB entry 8v9a coloured by chain, top view.
Source organism: Norovirus GII
Primary publication:
Development of a broad-spectrum therapeutic Fc-nanobody for human noroviruses.
Hansman GS, Kher G, Svirina AD, Tame JRH, Hartley-Tassell L, Irie H, Haselhorst T, von Itzstein M, Rudd PA, Pancera M
J Virol e0070724 (2024)
PMID: 38953655

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-269100 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
VP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 542 amino acids
Theoretical weight: 59.47 KDa
Source organism: Norovirus GII
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A2H4Y915 (Residues: 1-542; Coverage: 100%)
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 19 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 62.704Å b: 71.156Å c: 78.386Å
α: 90° β: 110.04° γ: 90°
R-values:
R R work R free
0.186 0.185 0.213
Expression system: Escherichia coli

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