› 8vc3

Electron Microscopy
3.2Å resolution

Voltage gated potassium ion channel Kv1.2 in complex with DTx

Released:
DOI: 10.2210/pdb8vc3/pdb
PDB entry 8vc3 coloured by chain, front view.
PDB entry 8vc3 coloured by chain, side view.
PDB entry 8vc3 coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting.
Wu Y, Yan Y, Yang Y, Bian S, Rivetta A, Allen K, Sigworth FJ
OpenAccess logo bioRxiv (2024)
PMID: 37398110
Related structures: EMD-43131

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246894 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kunitz-type serine protease inhibitor homolog alpha-dendrotoxin Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 7.02 KDa
Source organism: Dendroaspis angusticeps
Expression system: Not provided
UniProt:
  • Canonical: P00980 (Residues: 2-59; Coverage: 98%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Potassium voltage-gated channel subfamily A member 2 Chains: B, C, D, E
Molecule details ›
Chains: B, C, D, E
Length: 536 amino acids
Theoretical weight: 60.59 KDa
Source organism: Rattus norvegicus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P63142 (Residues: 1-499; Coverage: 100%)
Gene name: Kcna2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand K 2 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-43131
Expression systems:
  • Not provided
  • Komagataella pastoris

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