› 8vfl

X-ray diffraction
1.23Å resolution

Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K

Released:
DOI: 10.2210/pdb8vfl/pdb
PDB entry 8vfl coloured by chain, front view.
PDB entry 8vfl coloured by chain, side view.
PDB entry 8vfl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
Parkins A, Pilien AVR, Wolff AM, Argueta C, Vargas J, Sadeghi S, Franz AH, Thompson MC, Pantouris G
J Med Chem (2024)
PMID: 38670943

Function and Biology Details

Reaction catalysed: 
D-dopachrome = 5,6-dihydroxyindole + CO(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151620 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-dopachrome decarboxylase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 117 amino acids
Theoretical weight: 12.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30046 (Residues: 2-118; Coverage: 99%)
Gene name: DDT
Sequence domains: Macrophage migration inhibitory factor (MIF)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3
Unit cell:
a: 84.351Å b: 84.351Å c: 41.032Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.145 0.143 0.18
Expression system: Escherichia coli

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